Mounjaro and Ozempic are two medicines that enable you to with diabetes and weight administration. However is there a winner within the battle between Mounjaro and Ozempic?
Weight problems is a world pandemic. Based on the World Well being Group (WHO), grownup weight problems worldwide greater than doubled between 1990 and 2022. This has led to extra well being points, together with heart problems, diabetes, neuropathy, continual respiratory illness, and digestive points. Sustaining a wholesome weight is a serious concern on this state of affairs. Nonetheless, pursuing weight reduction rapidly leads folks to search out drug options geared toward managing diabetes, which additionally results in weight reduction. Ozempic and Mounjaro are two such weight reduction medicine which have brought on agitation worldwide. Are they related or completely different? Let’s break down the dialogue of Ozempic and Munjaro for you!
How does Mounjaro work?
Mounjaro (Tirzepatide) is a brand new injectable agent developed for the therapy of kind 2 diabetes, however can also be used as a weight reduction drug. “It’s a twin glucose-dependent insulintropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist,” says diabetic Dr. Shankar Kumar Venkatarayaraju. Due to this fact, it mimics the results of each GIP and GLP-1 hormones, which management blood glucose ranges, scale back urge for food, and results in weight reduction.
Medication obtainable with prefilled pen are administered as soon as every week through subcutaneous injection. That’s, it’s injected underneath the pores and skin of the stomach, thighs, or higher arms. It has been authorized by the US Meals and Drug Administration for kind 2 diabetes and is used off-label for weight problems.
How does Ozempic work?
Ozempic (Semaglutide) is a weekly injectable treatment devoted to kind 2 diabetes administration, and is used off-label for weight reduction. “It’s a GLP-1 receptor agonist that mimics endogenous glucagon-like peptide-1,” specialists share. It helps elevate ranges of intestinal hormone, Incletin, and produce extra insulin if mandatory. It additionally helps scale back the quantity of sugar produced by the liver, slowing down meals digestion. These mechanisms assist decrease blood sugar ranges and contribute to weight reduction.
Mounjaro vs Ozempic: What are the similarities?
Each medicine are related in a number of methods.
1. Weight reduction just isn’t authorized
Mounjaro has not been authorized for weight reduction by the FDA, regardless of its energetic ingredient, tilzepatide, which has obtained a inexperienced sign for weight reduction underneath the model identify Zepbound. Equally, Ozempic just isn’t authorized for this objective. It’s Wegovy that was authorized by the FDA for weight administration. Wegovy additionally makes use of Semaglutide, the principle ingredient in Ozempic.
2. Weekly Injectables
As for Mounjaro vs Ozempic, each are weekly injectable medicines used to deal with kind 2 diabetes and function weight reduction medicines. They decrease blood sugar ranges by means of the incretin hormone pathway, suppress urge for food, and result in weight reduction.
3. Subcutaneous administration
Each medicine are administered subcutaneously and require dose titration (gradual addition of 1 answer of already recognized focus). These are vital as they will scale back gastrointestinal uncomfortable side effects comparable to nausea, vomiting, and diarrhea.
“Additionally, each medicine beneficial after the failure of first-line brokers, comparable to metformin, exhibit favorable cardiovascular and metabolic profiles and are usually not appropriate for kind 1 diabetes,” says Dr Venkatalayaraju.
Mounjaro vs Ozempic: What is the distinction between them?
Some key variations between Mounjaro and Ozempic are:
1. Mounjarovs Ozempic: Elements and Mechanisms
Mounjaro (Tirzepatide) is a twin GIP/GLP-1 receptor agonist, whereas Ozempic (Semaglutide) targets GLP-1 receptors solely. This double focusing on in Mounjaro has a probably constructive impact on metabolism and will help you drop some pounds.
2. Mounjarovs Ozempic: Dosage
Each are administered subcutaneously as soon as every week, however the doses differ. “Mounjaro is offered in doses of two.5-15 mg every week, whereas Ozempic is normally titrated to 2 mg,” says an knowledgeable.
3. Mounjarovs Ozempic: Security
Launched within the US in 2017, Ozempic has broader long-term information, together with constructive cardiovascular outcomes in kind 2 diabetes sufferers. “The long-term security of Munjaro continues to be being evaluated, however the early information is promising,” in line with Dr. Venkatarayaraju.
Mounjaro vs Ozempic: Which is healthier?
From a scientific efficacy perspective, Munjaro seems to be superior to Ozempic in each glycemic management and weight reduction. Throughout the research printed in JAMA Inside Medication, individuals who had been chubby or overweight used tilzepatide and semaglutide. They skilled a big weight reduction when utilizing tilzepatide.
“However ‘higher’ additionally relies on patient-specific elements. Ozempic has sturdy cardiovascular information, together with FDA approval to cut back main cardiovascular occasions in high-risk folks. Mounjaro does not have this label but,” the knowledgeable says.
Within the battle between Mounjaro vs Ozempic, the previous could also be most well-liked if most weight reduction and glycemic management are the principle targets. If cardiovascular safety is a precedence, Ozempic could also be chosen.
Mounjaro vs Ozempic: Uncomfortable side effects
Among the uncomfortable side effects embrace:
Uncomfortable side effects of Mounjaro
- Stomach bloating
- stomach ache
- constipation
- bloating
- diarrhea
- nausea
- Lack of urge for food
- Discomfort and discoloration across the space the place the drugs was injected
Uncomfortable side effects of Ozempic
- stomach ache
- constipation
- diarrhea
- Indigestion
- Discomfort across the injection space
These uncomfortable side effects of Ozempic and Mounjaro could also be non permanent, however there can also be severe dangers. “They’re uncommon, however those that use each can have pancreatitis, thyroid tumors, and gallbladder illness,” specialists say.
There isn’t any clear winner within the Mounjaro vs Ozempic dialogue. Though their energetic substances differ, their well being targets, uncomfortable side effects, and administration routes overlap significantly.
Associated FAQs
How a lot weight can I lose in 6 weeks with Ozempic?
You would lose about 2% of your physique weight within the first 6 weeks with Ozempic. Nonetheless, you have to eat a nutritious diet and interact in common bodily exercise.
Can I swap from Ozempic to Mounjaro?
Sure, the transition from Ozempic to Munjaro is feasible and might be helpful for individuals who want higher glycemic management or enhanced weight reduction. This swap have to be achieved underneath medical supervision.
